Maitake Mushroom Extract
Clinical studies have shown benefits for patients with cancer, and also for patients with PCOS.
Japanese studies using an injectable type of maitake-D have found that it boosted the immune system and slowed or stopped the spread of breast and liver cancer in animal studies.
A phase 1 study in the USA is looking to see whether beta glucan can help a biological therapy called rituximab to work better. It is for young patients with lymphoma or leukemia that has come back after previous treatment.
Max Dose: Add 1-3g daily to food or drink as part of a balanced diet (one level 5ml teaspoon = 2g)
Medicinal Mushrooms - A brief guide written by Martin Powell.
Martin is a biochemist and a Chinese herbalist who has worked with mushroom nutrition for over 20 years. He lectures at the University of Westminster and is the author of Medicinal Mushrooms - a Clinical Guide. As well as running a clinical practice he continues to research mushrooms health benefits and runs seminars on their clinical uses for doctors and health care professionals in the UK and world wide. D.Atkinson Mushroom Extracts All of our mushroom extracts are produced for us by Martin Powell. Our products are practitioner strength and are produced to the highest standards.
Disclaimer: The information below is intended for educational use and is not meant to be used to diagnose or treat any medical condition. Anyone who is experiencing any symptoms, has been diagnosed with or suspects they may have a medical condition should contact a medical doctor or appropriately qualified health professional.
Main active components
Polysaccharides are the principal active components in Maitake, with several fractions, including: D-fraction and MD-fraction, showing strong immunological activity1, 2. Traditional use Most traditional sources do not mention Maitake and it appears that it was often not differentiated from Umbrella Polypore (also known as Grifola umbellata), of which it is said that ‘long term use makes one feel happy and vigorous and look younger’.
Main Health Benefits
Cancer Impressive results have been reported from the use of Maitake polysaccharide extracts, or combinations of polysaccharide extracts and fruiting body, with one study using 40-100mg MDfraction and 4-6g powdered fruiting body reporting cancer regression or significant symptom improvement in 58% of liver cancer patients, 68% of breast cancer patients and 62% of lung cancer patients. Similar results have been reported using combinations of D-fraction and powdered fruiting body and improvements in immunecompetent cell activities have also been reported when taken in conjunction with chemotherapy3, 4. Polysaccharide extracts of Umbrella Polypore are also licensed as anti-cancer agents in China, with improved treatment outcomes and quality of life indicators in a number of cancers, including: lung, liver, leukaemia, bladder, nose and throat5.
Diabetes: Several studies report significant improvement in blood sugar levels in type II diabetes patients from using purified Maitake polysaccharides. Positive results have also been reported from inclusion of crude Maitake powder in the diet of diabetic animal models (20% of food, or 1g/day in a mouse model)6, 7. Medicinal Mushrooms A brief guide written by Martin Powell.
Polycystic Ovary Syndrome: (PCOS) In the majority of cases, PCOS is associated with some level of insulin resistance and Maitake polysaccharide extracts also show promise as agents for helping address this condition8 . In one Japanese study, ovulation was observed in 20 of the 26 women given a Maitake polysaccharide extract and 6 of 8 women who failed to ovulate after being treated with clomiphene citrate did so after being given the polysaccharide extract. In addition, all 3 women who expressed an interest in becoming pregnant were able to do so9.
Polysaccharide extracts or combinations of extract and fruiting body have been favoured clinically at doses of 3-6g/day.
References: 1. Maitake extracts and their therapeutic potential - A review. Mayell M. Alt Med Rev, 2001;6(1). 2. Grifola frondosa (Dicks.: Fr.). Gray SF (Maitake Mushroom): medicinal properties,active compounds, and biotechnological cultivation. Boh B, Berovic MM. Int J Med Mush. 2007;9(2):10. 3. Maitake D-fraction: healing and preventive potential for cancer. Nanba H. J Orthomolecular Med. 1997;12:43-49. 4. Can Maitake MD-fraction aid cancer patients? Kodama N, Komuta K, Nanba H. Alt Med Rev. 2002;(7)3:236-9. 5. Chinese Medical Herbology and Pharmacology. Chen JK, Chen TT. 2001:386. Pub. Art of Medicine Press. 6. Anti-diabetic activity present in the fruit body of Grifola frondosa (Maitake). Kubo K, Aoki H, Nanba H. Biol Pharm Bull. 1994;17:1106-1110. 7. A possible hypoglycemic effect of maitake mushroom on type 2 diabetic patients. Konno S et al. Diabetic Med. 2001. Dec; 18(12):1010. 8. Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan. Teede H, Deeks A and Moran L. BMC Medicine 2010, 8:41. 9. Maitake Mushroom (Grifola frondosa) Extract Induces Ovulation in Patients with Polycystic Ovary Syndrome: A Possible Monotherapy and a Combination Therapy After Failure with First-Line Clomiphene Citrate. Chen J et al. The Journal of Alternative and Complementary Medicine, Vol. 16, No. 12, 2010, pp. 1295-1299. Medicinal Mush
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